In vivo microdialysis and HPLC-EC separation of monoamine neurotransmitters is performed in the awake behaving rodent to determine neurochemical markers/pattern of transmitter release following pharmacological or environmental manipulations. Animals are housed in sound attenuated chambers to increase compound effect detection. Compounds can be given by a number of routes including: IP, SC, Oral, ICV.

Deliverables from these studies include: